June 26, 2017 — Stephen N. Birrell, M.D., Ph.D., presented breakthrough findings into the reduction of mammographic breast density at the 8th International Breast Densitometry and Cancer Risk Assessment Conference in San Francisco, California. The conference, Co-Chaired by University of California, San Francisco, and Karolinska Institutet; included presentations and posters by researchers from institutions across the world, including the Mayo Clinic and Queen Mary University of London.
Birrell, chief medical officer of HAVAH Therapeutics, undertook a study to examine the effect of the company’s T+Ai (testosterone plus aromatase inhibitor) therapy that intends to mimic the effects of tamoxifen by reducing mammographic breast density in pre-menopausal women without perturbations in hypothalamic-pituitary function….
…In conclusion, testosterone combined with anastrozole is an effective method of reducing high mammographic breast density in pre-menopausal women. This is achieved by manipulating the amplified hormone catalytic enzymatic system of high mammographic breast density tissue to effect an alteration in the breast tissue estrogen to testosterone ratio; thus inducing a state of breast tissue involution commensurate with that occurring with tamoxifen chemoprevention. This was achieved with excellent tolerance and no adverse effect on hypothalamic-pituitary function.
